SeoulTech Researchers Propose a Novel Method to Shed Light on PFOS-Induced Neurotoxicity | PR Newswire [Video]

The strategy simultaneously extracts lipids and metabolites from zebrafish embryos to study perfluorooctanesulfonate (PFOS)-induced neurotoxicity

, /PRNewswire/ — The term “omics” refers to the study of entirety of molecular mechanisms happening inside an organism. With the advent of omics technologies like transcriptomics, proteomics, metabolomics, and lipidomics, our understanding of molecular pathways of toxic environmental pollutants has deepened. But most environmental toxicology studies are still dependent on a single-omics analyses, leading to gaps in our understanding of integrated toxicity pathways of pollutants. Researchers from all over the world have been trying to build reliable biomolecule analyses by designing multi-omics studies from a single biological sample. Although such advances have been reported from various model systems like mammalian cells, Caenorhabditis elegans, etc., toxicology studies on zebrafish are still based on a single-omics analyses using individually prepared biological samples. However, selection of appropriate extraction solvents and pooling size for accurate omics analyses is still …