Mounjaro leads to significantly more weight loss than Ozempic, study suggests [Video]

People taking tirzepatide injections lost more weight and were more likely to reach specific weight loss targets than those taking semaglutide, according to a new study.

Researchers from Truveta, a health data analytics company, analyzed electronic health records for more than 18,000 adults, all of whom had overweight or obesity, who were taking these medications in the real world between May 2022 and September 2023. The findings were published Monday in the JAMA Internal Medicine medical journal.

Both medications were effective — the vast majority of people taking either tirzepatide or semaglutide lost at least 5% of their starting body weight after one year of use. But 82% of people taking tirzepatide reached this important clinical benchmark, compared with about 67% of those taking semaglutide. And people taking tirzepatide were more than twice as likely to lose at least 15% of their starting weight than those taking semaglutide — about 42% …