Just the Facts: Tryptamine Therapeutics doses first patient in obesity-focused psilocin study [Video]

Proactive’s Tylah Tully breaks down Just the Facts of the latest news from Tryptamine Therapeutics Ltd (ASX:TYP, OTC:TYPTF).

The company has dosed the first participant in its Phase 1b trial of TRP-8803, a psilocin-based IV infusion, targeting obese individuals.

The trial, conducted at CMAX Clinical Research in Adelaide, involves three obese participants and aims to compare pharmacokinetics between obese and non-obese groups.
The initial treatment lasted 140 minutes.

TRP-8803, designed for faster onset and precise control of the psychedelic state, offers neuroplastic benefits that may lead to adaptive changes in the brain, enhancing clinical outcomes.
The trial builds on earlier Phase 1 results that demonstrated safety, efficacy, and optimal dosing rates.

Interim results from the obese cohort are expected before year-end. This data will refine dosing protocols for future Phase 2 trials, which will explore specific indications, including weight-related conditions such as Binge Eating Disorder.

The study highlights the cost-effectiveness of the initiative and its role in expanding the company’s dataset for broader applications.

Tryptamine’s management is currently evaluating opportunities for Phase 2 trials and plans to provide updates as they progress.

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